For research use only. Not for therapeutic Use.
20S-protopanaxadiol (aPPD) is a metabolite of ginseng saponins, inhibits Akt activity and induces apoptosis in various tumor cells[1].
20S-protopanaxadiol treatment upregulates the flotillin-1 level in the rafts of N2a cells to 142.91±10.71% of the control. 20S-protopanaxadiol can have an opposite effect on raft resident protein flotillin-1, depending on the cell type[1].
| Catalog Number | I003082 |
| CAS Number | 30636-90-9 |
| Synonyms | (3S,5R,8R,9R,10R,12R,13R,14R,17S)-17-[(2S)-2-hydroxy-6-methylhept-5-en-2-yl]-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,12-diol |
| Molecular Formula | C30H52O3 |
| Purity | ≥95% |
| InChI | InChI=1S/C30H52O3/c1-19(2)10-9-14-30(8,33)20-11-16-29(7)25(20)21(31)18-23-27(5)15-13-24(32)26(3,4)22(27)12-17-28(23,29)6/h10,20-25,31-33H,9,11-18H2,1-8H3/t20-,21+,22-,23+,24-,25-,27-,28+,29+,30-/m0/s1 |
| InChIKey | PYXFVCFISTUSOO-HKUCOEKDSA-N |
| SMILES | CC(=CCCC(C)(C1CCC2(C1C(CC3C2(CCC4C3(CCC(C4(C)C)O)C)C)O)C)O)C |
| Reference | [1]. iu Y, Yang G, Bu X, et al. Cell-type-specific regulation of raft-associated Akt signaling. Cell Death Dis. 2011;2(4):e145. Published 2011 Apr 14. |
