2,2'-((6,6'-(2,4-Di(pyridin-2-yl)cyclobutane-1,3-diyl)bis(1H-indazole-6,3-diyl))bis(sulfanediyl))bis(N-methylbenzamide)

• CAT Number: C000645
• CAS Number: 1428728-83-9
• Molecular Formula: C₄₄H₃₆N₈O₂S₂
• Molecular Weight: 772.94
• Purity: ≥95%
• Synonyms: Axitinib Dimer Impurity
• Solubility: DMF (Slightly), DMSO (Slightly)
• Appearance: Pale Beige Solid
• Storage: -20°C

2,2′-((6,6′-(2,4-Di(pyridin-2-yl)cyclobutane-1,3-diyl)bis(1H-indazole-6,3-diyl))bis(sulfanediyl))bis(N-methylbenzamide) (CAT: C000645) is an impurity that can be found in Axitinib, a tyrosine kinase inhibitor used in cancer therapy. Axitinib acts by inhibiting specific tyrosine kinase enzymes involved in signaling pathways that promote tumor growth and angiogenesis. This impurity, although not the active ingredient, can still influence the overall properties and behavior of the drug substance.

Reference

Wasser, K., et al.: Eur. Radiol., 13, 80 (2003), Park, J., et al.: Clin. Cancer Res., 8, 1172 (2002), Bergers, G., et al.: J. Clin. Invest., 111, 1287 (2003),