2,2'-Anhydrouridine

• CAT Number: I019565
• CAS Number: 3736-77-4
• Molecular Formula: C₉H₁₀N₂O₅
• Molecular Weight: 226.19
• Purity: ≥95%
• Storage: -20°C
• IUPAC Name: (2R,4R,5R,6S)-5-hydroxy-4-(hydroxymethyl)-3,7-dioxa-1,9-diazatricyclo[6.4.0.02,6]dodeca-8,11-dien-10-one
• InChI: InChI=1S/C9H10N2O5/c12-3-4-6(14)7-8(15-4)11-2-1-5(13)10-9(11)16-7/h1-2,4,6-8,12,14H,3H2/t4-,6-,7+,8-/m1/s1
• InChIKey: UUGITDASWNOAGG-CCXZUQQUSA-N
• SMILES: C1=CN2[C@H]3[C@H]([C@@H]([C@H](O3)CO)O)OC2=NC1=O

2,2′-Anhydrouridine（Cat No.:I019565）is a nucleoside analog commonly used in biochemical and pharmaceutical research. Its unique anhydro structure allows it to act as a potent inhibitor of RNA metabolism, providing valuable insights into RNA synthesis, modification, and degradation. This compound is instrumental in studying the mechanisms of antiviral and anticancer therapies, as well as in the development of nucleotide-based drugs. Additionally, 2,2′-Anhydrouridine serves as a reference material in analytical applications, aiding in the characterization of nucleoside analogs and their metabolic pathways, enhancing drug discovery efforts.

Reference

[1]. Drabikowska AK, et al. Inhibitor properties of some 5-substituted uracil acyclonucleosides, and 2,2′-anhydrouridines versus uridine phosphorylase from E. coli and mammalian sources. Biochem Pharmacol. 1987 Dec 1;36(23):4125-8.