2,2,2-Trichloroethanol

• CAT Number: R044578
• CAS Number: 115-20-8
• Molecular Formula: C2H3Cl3O
• Molecular Weight: 149.4
• Purity: ≥95%
• Synonyms: 2,2,2-Trichloro-ethanol; (Hydroxymethyl)trichloromethane; 2,2,2-Trichloroethyl alcohol; NSC 66407; Trichlorethanol; Trichloroethanol; β,β,β-Trichloroethanol
• Target: Metabolic Enzyme/Protease
• Storage: Store at RT
• IUPAC Name: 2,2,2-trichloroethanol
• InChI: InChI=1S/C2H3Cl3O/c3-2(4,5)1-6/h6H,1H2
• InChIKey: KPWDGTGXUYRARH-UHFFFAOYSA-N
• SMILES: C(C(Cl)(Cl)Cl)O

2,2,2-Trichloroethanol（Cat No.:R044578） is the active metabolite of chloral hydrate, a sedative-hypnotic drug. It acts as an agonist for the non-canonical K2P channels TREK-1 and TRAAK. These channels are involved in the regulation of neuronal excitability and play a role in pain perception, anesthesia, and other physiological processes. By activating these channels, 2,2,2-Trichloroethanol can modulate neuronal activity, leading to sedative and hypnotic effects.