2',3'-cGMP sodium

• CAT Number: M087500
• CAS Number: 15718-49-7
• Molecular Formula: C10H11N5NaO7P
• Molecular Weight: 367.19
• Purity: ≥95%
• Synonyms: sodium;9-[(3aR,4R,6R,6aR)-6-(hydroxymethyl)-2-oxido-2-oxo-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3,2]dioxaphosphol-4-yl]-2-amino-1H-purin-6-one
• InChI: InChI=1S/C10H12N5O7P.Na/c11-10-13-7-4(8(17)14-10)12-2-15(7)9-6-5(3(1-16)20-9)21-23(18,19)22-6;/h2-3,5-6,9,16H,1H2,(H,18,19)(H3,11,13,14,17);/q;+1/p-1/t3-,5-,6-,9-;/m1./s1
• InChIKey: KJPSSHNIEXRDDG-GWTDSMLYSA-M
• SMILES: C1=NC2=C(N1C3C4C(C(O3)CO)OP(=O)(O4)[O-])N=C(NC2=O)N.[Na+]

2′,3′-cGMP sodium (Cat No.: M087500) is the sodium salt form of 2′,3′-cyclic guanosine monophosphate, a naturally occurring cyclic nucleotide distinct from the more common 3′,5′-cGMP. It features a phosphate group bridging the 2′ and 3′ hydroxyls of the ribose ring. This molecule is of interest in nucleotide signaling studies, RNA degradation pathways, and cellular stress responses. It serves as a biochemical tool for investigating non-canonical cyclic nucleotide signaling and enzymatic processes involving cyclic nucleotides, particularly in neurobiology, immunology, and molecular biology research.

Reference

[1]. Sokurenko JV, et al. [Identification of 2′,3′-cGMP as an intermediate of RNA catalytic cleavage by binase and evaluation of its biological action]. Bioorg Khim. 2015 Jan-Feb;41(1):37-43. Russian.
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[2]. Boadu E, et al. Inhibition by guanosine cyclic monophosphate (cGMP) analogues of uptake of [(3)H]3′,5′-cGMP without stimulation of ATPase activity in human erythrocyte inside-out vesicles. Biochem Pharmacol. 2001 Aug 15;62(4):425-9.
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