For research use only. Not for therapeutic Use.
2′,3′-cGMP sodium, a cGMP analogue, is an intermediate of RNA catalytic cleavage by binase[1].
2′,3′-cGMP sodium (10 nM-100 μM, 120 min) reduces the active transport of [3H]3’,5’-cGMP into inside-out vesicles from human erythrocytes[2].
2′,3′-cGMP sodium (2 μM) increases the ATPase activity[2].
| CAS Number | 15718-49-7 |
| Synonyms | sodium;9-[(3aR,4R,6R,6aR)-6-(hydroxymethyl)-2-oxido-2-oxo-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3,2]dioxaphosphol-4-yl]-2-amino-1H-purin-6-one |
| Molecular Formula | C10H11N5NaO7P |
| Purity | ≥95% |
| InChI | InChI=1S/C10H12N5O7P.Na/c11-10-13-7-4(8(17)14-10)12-2-15(7)9-6-5(3(1-16)20-9)21-23(18,19)22-6;/h2-3,5-6,9,16H,1H2,(H,18,19)(H3,11,13,14,17);/q;+1/p-1/t3-,5-,6-,9-;/m1./s1 |
| InChIKey | KJPSSHNIEXRDDG-GWTDSMLYSA-M |
| SMILES | C1=NC2=C(N1C3C4C(C(O3)CO)OP(=O)(O4)[O-])N=C(NC2=O)N.[Na+] |
| Reference | [1]. Sokurenko JV, et al. [Identification of 2′,3′-cGMP as an intermediate of RNA catalytic cleavage by binase and evaluation of its biological action]. Bioorg Khim. 2015 Jan-Feb;41(1):37-43. Russian. [2]. Boadu E, et al. Inhibition by guanosine cyclic monophosphate (cGMP) analogues of uptake of [(3)H]3′,5′-cGMP without stimulation of ATPase activity in human erythrocyte inside-out vesicles. Biochem Pharmacol. 2001 Aug 15;62(4):425-9. |
