2,3-Dihydroxy-4-methoxyacetophenone

• CAT Number: R064672
• CAS Number: 708-53-2
• Molecular Formula: C9H10O4
• Molecular Weight: 182.17
• Purity: ≥95%
• Synonyms: 1-(2,3-dihydroxy-4-methoxyphenyl)ethanone
• InChI: InChI=1S/C9H10O4/c1-5(10)6-3-4-7(13-2)9(12)8(6)11/h3-4,11-12H,1-2H3
• InChIKey: VCONERRCKOKCHE-UHFFFAOYSA-N
• SMILES: CC(=O)C1=C(C(=C(C=C1)OC)O)O

2,3-Dihydroxy-4-methoxyacetophenone is a neuroprotective compound from Cynenchum paniculatum. 2,3-Dihydroxy-4-methoxyacetophenone improves cognitive function and may has the potential for the treatment of Alzheimer’s disease research[1].
2,3-Dihydroxy-4-methoxyacetophenone protects HT22 cells on glutamate induced cell-death in a dose-dependent manner (EC50=10.94 μM). 2,3-Dihydroxy-4-methoxyacetophenone inhibits [Ca2+] accumulation in HT22 cells and has antioxidantive activity[1].
2,3-dihydroxy-4-methoxyacetophenone (50mg/kg; po) improves the impairment of spatial memory induced by scopolamine[1].

Reference

[1]. Jin Bae Weon, et al. The Ameliorating Effects of 2,3-dihydroxy-4-methoxyacetophenone on Scopolamine-Induced Memory Impairment in Mice and Its Neuroprotective Activity. Bioorg Med Chem Lett. 2013 Dec 15;23(24):6732-6.
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