For research use only. Not for therapeutic Use.
Thromboxane B<sub>2</sub> (TXB<sub>2</sub>) is released in substantial quantities from aggregating platelets and metabolized during circulation to 11-<wbr></wbr>dehydro TXB<sub>2</sub> and 2,3-<wbr></wbr>dinor TXB<sub>2</sub>. 2,3-<wbr></wbr>dinor TXB<sub>2</sub> is an abundant urinary metabolite of TXB<sub>2</sub> and can be used as a marker for <em>in vivo</em> TXA<sub>2</sub> synthesis. In healthy male volunteers, the median excretion of 2,3-<wbr></wbr>dinor TXB<sub>2</sub> is 10.3 ng/hour (138 pg/mg creatine).
| Catalog Number | R015430 |
| CAS Number | 63250-09-9 |
| Synonyms | 2,3-dinor TXB2 |
| Molecular Formula | C18H30O6 |
| Purity | ≥95% |
| Storage | -20°C |
| IUPAC Name | (Z)-5-[(2R,3S,4S,6R)-4,6-dihydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]oxan-3-yl]pent-3-enoic acid |
| InChI | InChI=1S/C18H30O6/c1-2-3-4-7-13(19)10-11-16-14(8-5-6-9-17(21)22)15(20)12-18(23)24-16/h5-6,10-11,13-16,18-20,23H,2-4,7-9,12H2,1H3,(H,21,22)/b6-5-,11-10+/t13-,14-,15-,16+,18+/m0/s1 |
| InChIKey | RJHNVFKNIJQTQF-JORIIADHSA-N |
| SMILES | CCCCCC(C=CC1C(C(CC(O1)O)O)CC=CCC(=O)O)O |
| Reference | 1.Ciabattoni, G.,Pugliese, F.,Davi, G., et al. Fractional conversion of thromboxane B2 to urinary 11-dehydrothromboxane B2 in man. Biochimica et Biophysica Acta 992, 66-70 (1989). |
