2,3-Diphosphoglyceric acid pentasodium

• CAT Number: R054792
• CAS Number: 1287756-01-7
• Molecular Formula: C3H3Na5O10P2
• Molecular Weight: 375.95
• Purity: ≥95%
• Synonyms: pentasodium;2,3-diphosphonatooxypropanoate
• InChI: InChI=1S/C3H8O10P2.5Na/c4-3(5)2(13-15(9,10)11)1-12-14(6,7)8;;;;;/h2H,1H2,(H,4,5)(H2,6,7,8)(H2,9,10,11);;;;;/q;5*+1/p-5
• InChIKey: KPRMRMXBVAUXKZ-UHFFFAOYSA-I
• SMILES: C(C(C(=O)[O-])OP(=O)([O-])[O-])OP(=O)([O-])[O-].[Na+].[Na+].[Na+].[Na+].[Na+]

2,3-Diphosphoglyceric acid (2,3-DPG) pentasodium is an intermediate of the glycolytic pathway. 2,3-Diphosphoglyceric acid pentasodium stabilizes the deoxygenated form of hemoglobin by allosteric binding and facilitates oxygen release at tissue sites. 2,3-Diphosphoglyceric acid pentasodium binds to hemoglobin and decrease its affinity for oxygen[1][2].

Reference

[1]. Shakil H. Merchant MD, et al. 24 – Molecular Diagnosis in Hematopathology. Hematopathology (Second Edition).2012, 679-726.

[2]. Płoszczyca K, et al. Red Blood Cell 2,3-Diphosphoglycerate Decreases in Response to a 30 km Time Trial Under Hypoxia in Cyclists. Front Physiol. 2021 Jun 15;12:670977.
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