2,5-Anhydro-D-mannitol

• CAT Number: R020546
• CAS Number: 41107-82-8
• Molecular Formula: C6H12O5
• Molecular Weight: 164.157
• Purity: ≥95%
• Synonyms: NSC 129241
• Storage: -20°C
• IUPAC Name: (2R,3S,4S,5R)-2,5-bis(hydroxymethyl)oxolane-3,4-diol
• InChI: InChI=1S/C6H12O5/c7-1-3-5(9)6(10)4(2-8)11-3/h3-10H,1-2H2/t3-,4-,5-,6-/m1/s1
• InChIKey: MCHWWJLLPNDHGL-KVTDHHQDSA-N
• SMILES: C(C1C(C(C(O1)CO)O)O)O

2,5-Anhydro-D-mannitol is an antimetabolic fructose analogue that increases food intake in rats at doses of 50-800 mg/kg by inhibiting gluconeogenesis and glycogenolysis in the liver.. It is phosphorylated in the liver, which decreases available ATP and signals eating behavior in rats through a vagal nerve mechanism.