2,5-Dioxopyrrolidine Sacubitril

• CAT Number: C000641
• CAS Number: 1038924-97-8
• Molecular Formula: C₂₄H₂₇NO₄
• Molecular Weight: 393.48
• Purity: ≥95%
• Synonyms: (2R,4S)-5-(Biphenyl-4-yl)-4-(2,5-dioxopyrrolidin-1-yl)-2-methylpentanoic Acid Ethyl Ester; 2,5-Dioxopyrrolidine Sacubitril; Sacubitril Impurity 2
• Solubility: Chloroform (Sparingly), Ethyl Acetate (Slightly)
• Appearance: White to Off-White Waxy Solid
• Storage: 4°C

2,5-Dioxopyrrolidine Sacubitril(CAT: C000641) appears to be a compound related to Sacubitril, a medication used in combination with valsartan for the treatment of heart failure. In pharmaceutical chemistry, understanding and characterizing impurities like “Sacubitril Impurity 2” are crucial for ensuring the quality, safety, and efficacy of the final drug product. These impurities can arise during the drug synthesis process and need to be monitored and controlled to meet regulatory standards.

Reference

McMurray, J., et al.: N. Eng. J. Med., 371 (2014);