For research use only. Not for therapeutic Use.
During unfavorable environmental conditions, <em>C. elegans</em> larvae undergo arrest and form dauer larvae that can attach to other animals as a parasitic strategy for survival. DAF-<wbr></wbr>12 is an orphan nuclear hormone receptor that regulates dauer larva diapause, reproductive development, fat metabolism, and life cycle/longevity in <em>C. elegans</em>. DAF-<wbr></wbr>12 is required for entry into dauer when it is not bound to ligand by acting as a transcriptional repressor of target genes that favor reproductive development. (25S)-<wbr></wbr>Δ At 50 nM, (25S)-<wbr></wbr>Δ Thus, selective ligand modulators of DAF-<wbr></wbr>12 are a potential therapeutic approach to stop larvae progression during parasitic infection.
| Catalog Number | R064644 |
| CAS Number | 949004-12-0 |
| Synonyms | UPF-1404 |
| Molecular Formula | C27H42O3 |
| Purity | ≥95% |
| Storage | -20°C |
| IUPAC Name | (2S,6R)-6-[(5S,9R,10S,13R,14R,17R)-10,13-dimethyl-3-oxo-1,2,4,5,6,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl]-2-methylheptanoic acid |
| InChI | InChI=1S/C27H42O3/c1-17(6-5-7-18(2)25(29)30)22-10-11-23-21-9-8-19-16-20(28)12-14-26(19,3)24(21)13-15-27(22,23)4/h9,17-19,22-24H,5-8,10-16H2,1-4H3,(H,29,30)/t17-,18+,19+,22-,23+,24+,26+,27-/m1/s1 |
| InChIKey | SQTAVUCHOVVOFD-OBRBSRNPSA-N |
| SMILES | CC(CCCC(C)C(=O)O)C1CCC2C1(CCC3C2=CCC4C3(CCC(=O)C4)C)C |
| Reference | 1.Ogawa, A.,Streit, A.,Antebi, A., et al. A conserved endocrine mechanism controls the formation of dauer and infective larvae in nematodes. Current Biology 19, 67-71 (2009). |
