(2R)-Octyl-α-hydroxyglutarate

• CAT Number: I013067
• CAS Number: 1391194-67-4
• Molecular Formula: C13H24O5
• Molecular Weight: 260.33
• Purity: ≥95%
• Synonyms: (4R)-4-hydroxy-5-octoxy-5-oxopentanoic acid
• InChI: InChI=1S/C13H24O5/c1-2-3-4-5-6-7-10-18-13(17)11(14)8-9-12(15)16/h11,14H,2-10H2,1H3,(H,15,16)/t11-/m1/s1
• InChIKey: UJZOKTKSGUOCCM-LLVKDONJSA-N
• SMILES: CCCCCCCCOC(=O)C(CCC(=O)O)O

(2R)-Octyl-α-hydroxyglutarate ((2R)-Octyl-2-HG) is a modified form of D-isomer 2-Hydroxyglutarate.
Treatment of IDH1-WT HeLa cells with (2R)-Octyl-α-hydroxyglutarate, a modified form of 2-Hydroxyglutarate with high cellular uptake, results in a dose-dependent increase in DSBs in log-phase cells. It has been used to examine the contribution of D-2-Hydroxyglutarate to the oxidative mitochondrial processes of IDH1-mutated cancer cells[1].

Reference

[1]. Sulkowski PL, et al. 2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologousrecombination and induces PARP inhibitor sensitivity. Sci Transl Med. 2017 Feb 1;9(375).
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