For research use only. Not for therapeutic Use.
(2S,3R)-Brassinazole, the enantiomer of Brassinazole (BRZ). Brassinazole inhibits brassinosteroid (BR) biosynthesis, via acting on the oxidative processes from 6-oxo-campestanol to teasterone. (2S,3R)-Brassinazole might be the most active form of Brz[1][2][3].
Brassinazole (0.5, 1, 5 μM) causes markedly deformed seedlings, whose morphology is similar to that of BR-deficient mutants. Brassinazole causes cress dwarfism, altering leaf morphology such as the typical downward curl and dark green appearance of Arabidopsis BR-deficient mutants. However, administration of 10 nM BR reversed dwarfism[1].
| Catalog Number | I041819 |
| CAS Number | 259200-31-2 |
| Synonyms | (2S,3R)-4-(4-chlorophenyl)-2-phenyl-3-(1,2,4-triazol-1-yl)butan-2-ol |
| Molecular Formula | C18H18ClN3O |
| Purity | ≥95% |
| InChI | InChI=1S/C18H18ClN3O/c1-18(23,15-5-3-2-4-6-15)17(22-13-20-12-21-22)11-14-7-9-16(19)10-8-14/h2-10,12-13,17,23H,11H2,1H3/t17-,18+/m1/s1 |
| InChIKey | YULDTPKHZNKFEY-MSOLQXFVSA-N |
| SMILES | CC(C1=CC=CC=C1)(C(CC2=CC=C(C=C2)Cl)N3C=NC=N3)O |
| Reference | [1]. Yoshida Shigeo, et al. Preparation of (1,2,4-triazolyl)alkanols as specific inhibitors of brassinosteroid biosynthesis: Japan, JP2000053657. 2000-02-22. [2]. Asami T, et al. Mode of action of brassinazole: a specific inhibitor of brassinosteroid biosynthesis[M]. 2000. [3]. T Asami, et al. Characterization of Brassinazole, a Triazole-Type Brassinosteroid Biosynthesis Inhibitor. Plant Physiol. 2000 May;123(1):93-100. |
