(2S,3S,5S)-5-Amino-1,6-diphenyl-2-([[thiazol-5-ylmethoxy)carbonyl]amino]hexan-3-yl 2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-3-methylbutanoate Hydrochloride

• CAT Number: C000384
• CAS Number: 959315-21-0
• Molecular Formula: C37H48N6O5S2
• Molecular Weight: 720.91
• Purity: ≥95%
• Synonyms: Ritonavir Impurity
• Solubility: DMSO (Slightly), Methanol (Sparingly)
• Appearance: Off-White to Light Beige Solid
• Storage: -20°C, Hygroscopic
• IUPAC Name: [(2S,3S,5S)-5-amino-1,6-diphenyl-2-(1,3-thiazol-5-ylmethoxycarbonylamino)hexan-3-yl] (2S)-3-methyl-2-[[methyl-[(2-propan-2-yl-1,3-thiazol-4-yl)methyl]carbamoyl]amino]butanoate
• InChI: InChI=1S/C37H48N6O5S2/c1-24(2)33(42-36(45)43(5)20-29-22-49-34(40-29)25(3)4)35(44)48-32(18-28(38)16-26-12-8-6-9-13-26)31(17-27-14-10-7-11-15-27)41-37(46)47-21-30-19-39-23-50-30/h6-15,19,22-25,28,31-33H,16-18,20-21,38H2,1-5H3,(H,41,46)(H,42,45)/t28-,31-,32-,33-/m0/s1
• InChIKey: WDHQCUZKKFEVBI-XGKFQTDJSA-N
• SMILES: CC(C)C1=NC(=CS1)CN(C)C(=O)N[C@@H](C(C)C)C(=O)O[C@@H](C[C@H](CC2=CC=CC=C2)N)[C@H](CC3=CC=CC=C3)NC(=O)OCC4=CN=CS4

(2S,3S,5S)-5-Amino-1,6-diphenyl-2-([[thiazol-5-ylmethoxy)carbonyl]amino]hexan-3-yl 2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-3-methylbutanoate hydrochloride(CAT: C000384) is a prodrug of Ritonavir, a selective HIV protease inhibitor. Ritonavir blocks the HIV-1 protease enzyme, preventing the cleavage of viral polyproteins necessary for viral maturation, thereby inhibiting viral replication. As a prodrug, this compound is designed to improve Ritonavir’s bioavailability and pharmacokinetics, potentially enhancing therapeutic efficacy and minimizing side effects. It plays a crucial role in antiretroviral therapy for HIV/AIDS, supporting viral suppression and disease management. This compound is valuable in infectious disease research, aiding in the development of more effective HIV treatments.