2S,6S-Hydroxynorketamine hydrochloride

• CAT Number: I011375
• CAS Number: 1430202-70-2
• Molecular Formula: C12H15Cl2NO2
• Molecular Weight: 276.16
• Purity: ≥95%
• Synonyms: (2S,6S)-2-Amino-2-(2-chlorophenyl)-6-hydroxycyclohexanone hydrochloride
• Solubility: Soluble to 50 mM in water and to 100 mM in DMSO
• Storage: Store at RT
• IUPAC Name: (2S,6S)-2-amino-2-(2-chlorophenyl)-6-hydroxycyclohexan-1-one;hydrochloride
• InChI: InChI=1S/C12H14ClNO2.ClH/c13-9-5-2-1-4-8(9)12(14)7-3-6-10(15)11(12)16;/h1-2,4-5,10,15H,3,6-7,14H2;1H/t10-,12-;/m0./s1
• InChIKey: ZQJVHBJDLMIKJK-JGAZGGJJSA-N
• SMILES: C1CC(C(=O)C(C1)(C2=CC=CC=C2Cl)N)O.Cl

2S,6S-Hydroxynorketamine hydrochloride (Cat.No: I011375), also known as HNK, is a metabolite of ketamine. HNK has shown potential for the treatment of depression and neuropathic pain, with fewer side effects than ketamine. It acts as a non-competitive NMDA receptor antagonist, and also targets the AMPA receptor. HNK is currently being studied for its therapeutic potential in various clinical trials.