For research use only. Not for therapeutic Use.
7-<wbr></wbr>dehydro Cholesterol (7-<wbr></wbr>DHC) is an immediate precursor of cholesterol. It is reduced to cholesterol by the enzyme 3β-<wbr></wbr>hydroxysterol-<wbr></wbr>Δ 7-<wbr></wbr>DHC is elevated in rats treated with the DHCR7 inhibitor AY9944, an animal model of SLOS. 7-<wbr></wbr>DHC is subject to free radical oxidation (autoxidation), giving rise to several oxysterols which contribute to pathogenesis. Serum levels of 7-<wbr></wbr>DHC, largely derived from the liver, are approximately 0.3 μM in healthy individuals. In the skin, photolysis of 7-<wbr></wbr>DHC by ultraviolet light produces vitamin D<sub>3</sub> (Item No. <span class=/itemid/>11792</span>).
| Catalog Number | R050896 |
| CAS Number | 434-16-2 |
| Synonyms | Cholesta-5,7-dien-3β-ol; 7,8-Didehydrocholesterol; 7-Dehydrocholesterin; Provitamin D3. |
| Molecular Formula | C27H44O |
| Purity | ≥95% |
| Target | Endogenous Metabolite |
| Storage | -20°C |
| IUPAC Name | (3S,9S,10R,13R,14R,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,9,11,12,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-ol |
| InChI | InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 |
| InChIKey | UCTLRSWJYQTBFZ-DDPQNLDTSA-N |
| SMILES | CC(C)CCCC(C)C1CCC2C1(CCC3C2=CC=C4C3(CCC(C4)O)C)C |
