3-((2,6-dichlorobenzyl)amino)-6,7-dimethoxyindeno[1,2-c]pyrazol-4(1H)-one

• CAT Number: C000632
• CAS Number: 1201944-91-3
• Molecular Formula: C₁₉H₁₅Cl₂N₃O₃
• Molecular Weight: 404.25
• Purity: ≥95%
• Synonyms: [1,2-c]pyrazol-4(1H)-one, 3-[[(2,6-dichlorophenyl)methyl]amino]-6,7-dimethoxy-Indeno
• Solubility: DMSO (Slightly), Methanol (Slightly)
• Appearance: Light Yellow to Yellow Solid
• Storage: 4°C, Inert atmosphere

3-((2,6-dichlorobenzyl)amino)-6,7-dimethoxyindeno[1,2-c]pyrazol-4(1H)-one (CAT: C000632) is a chemical compound that falls under the category of indeno[1,2-c]pyrazole derivatives. These compounds have been studied for their potential as inhibitors of heme-regulated eukaryotic initiation factor 2a (HRI) kinase. HRI kinase plays a role in regulating protein synthesis, particularly in response to cellular stressors, and inhibitors of this kinase can have implications in various fields, including the development of pharmaceuticals targeting protein synthesis regulation.

Reference

Rosen, M. D., et al.: Bioorganic Med. Chem. Lett., 19, 6548-6551 (2009).