3-(Acetylamino)-2-[[[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]amino]carbonyl]benzoic Acid (Apremilast Benzoic Acid)

• CAT Number: C000052
• CAS Number: 2096492-41-8
• Molecular Formula: C₂₂H₂₆N₂O₈S
• Molecular Weight: 478.52
• Purity: ≥95%
• Synonyms: Apremilast Hydrolysis Impurity-2
• Solubility: DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Very Slightly)
• Appearance: Off-White to Pale Yellow Solid
• Storage: -20°C, Hygroscopic

(aS)-3-Ethoxy-4-methoxy-a-[(methylsulfonyl)methyl]-N-[(1S)-1-phenylethyl]-benzenemethanamine(CAT: C000052) is an impurity of Apremilast, which is an oral phosphodiesterase 4 (PDE4) inhibitor used for the treatment of psoriatic arthritis and moderate to severe plaque psoriasis. Apremilast exerts its therapeutic effects by modulating intracellular levels of cyclic adenosine monophosphate (cAMP), leading to anti-inflammatory and immunomodulatory effects.

Reference

Gan, E. et al.: BioDrugs, 27, 359 (2013); Pathan, E. et al.: Annal. Rheum. DIs., 72, 1475 (2013)