3-Amino-4-(2,4,5-trifluorophenyl)butanyl Sitagliptin

• CAT Number: C000439
• CAS Number: 2072867-07-1
• Molecular Formula: C₂₆H₂₃F₉N₆O₂
• Molecular Weight: 622.49
• Purity: ≥95%
• Synonyms: (R)-3-Amino-N-((R)-4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-yl)-4-(2,4,5-trifluorophenyl)butanamide
• Solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
• Appearance: White to Off-White Solid
• Storage: 4°C

3-Amino-4-(2,4,5-trifluorophenyl)butanyl Sitagliptin(CAT: C000439) is an impurity found in Sitagliptin. Sitagliptin is a trizolopyrazine dipeptidyl peptidase IV (DPP-IV) inhibitor. This class of compounds is utilized in the treatment of type II diabetes. Sitagliptin, in particular, has been approved for therapeutic use in managing this condition.

Reference

Kim, D., et al.: J. Med. Chem., 48, 141 (2005), Ahren, B., et al.: Eur. J. Pharmacol., 521 164 (2005), Bergman, A., et al: Clin. Ther., 28, 55 (2006)