3'-Azido-3'-deoxy-5-methylcytidine

• CAT Number: I019492
• CAS Number: 1282040-14-5
• Molecular Formula: C₁₀H₁₄N₆O₄
• Molecular Weight: 282.26
• Purity: ≥95%
• Target: HIV
• Storage: Store at -20°C
• IUPAC Name: 4-amino-1-[(2R,3R,4S,5S)-4-azido-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidin-2-one
• InChI: InChI=1S/C10H14N6O4/c1-4-2-16(10(19)13-8(4)11)9-7(18)6(14-15-12)5(3-17)20-9/h2,5-7,9,17-18H,3H2,1H3,(H2,11,13,19)/t5-,6-,7-,9-/m1/s1
• InChIKey: HQIDXEHGLJUNPT-JXOAFFINSA-N
• SMILES: CC1=CN(C(=O)N=C1N)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)N=[N+]=[N-])O

3′-Azido-3′-deoxy-5-methylcytidine（Cat No.:I019492）is a modified nucleoside analog used in antiviral and anticancer research. It features an azido group at the 3′-position and a methyl group at the 5′-position, which differentiates it from natural cytidine. This modification enhances its potential as a substrate for nucleotide analogs and inhibitors in DNA replication and repair processes. 3′-Azido-3′-deoxy-5-methylcytidine has shown promise in studies on HIV, hepatitis, and other viral infections, as well as in cancer therapy. It is valuable in investigating the effects of modified nucleosides in cellular and molecular mechanisms.

Reference

[1]. Singh IR, et al. Raltegravir is a potent inhibitor of XMRV, a virus implicated in prostate cancer and chronic fatigue syndrome. PLoS One. 2010 Apr 1;5(4):e9948.