3-Bromo-1-methyl-1H-indole-2-carbaldehyde

• CAT Number: M009363
• CAS Number: 499983-78-7
• PubChem Substance ID: 11368396
• Molecular Formula: C10H8BrNO
• Molecular Weight: 238.08
• Purity: ≥95%
• IUPAC Name: 3-bromo-1-methylindole-2-carbaldehyde
• InChI: InChI=1S/C10H8BrNO/c1-12-8-5-3-2-4-7(8)10(11)9(12)6-13/h2-6H,1H3
• InChIKey: XPLPNQFLFWXQRC-UHFFFAOYSA-N
• SMILES: CN1C2=CC=CC=C2C(=C1C=O)Br

3-Bromo-1-methyl-1H-indole-2-carbaldehyde(CAS 499983-78-7) is a purine nucleotide and an intermediate in the purine nucleotide cycle. It is converted into AMP and fumarate by adenylosuccinate lyase in the cytosol. Adenylosuccinic acid (10 µM) inhibits calcium-induced activation of non-selective cation channels in isolated rat brown adipocytes in a patch-clamp assay.

Reference

1.WAARDE, AREN VAN. "Operation of the purine nucleotide cycle in animal tissues." Biological Reviews 63.2 (1988): 259-298.
2.Halonen, J., and J. Nedergaard. "Adenosine 5?-Monophosphate Is a Selective Inhibitor of the Brown Adipocyte Nonselective Cation Channel." The Journal of membrane biology 188.3 (2002): 183-197.