3-Chlorogentisyl alcohol

• CAT Number: I043300
• CAS Number: 32744-80-2
• Molecular Formula: C7H7ClO3
• Molecular Weight: 174.58
• Purity: ≥95%
• Synonyms: 2-chloro-6-(hydroxymethyl)benzene-1,4-diol
• InChI: InChI=1S/C7H7ClO3/c8-6-2-5(10)1-4(3-9)7(6)11/h1-2,9-11H,3H2
• InChIKey: GUIGFYWMQAYTBT-UHFFFAOYSA-N
• SMILES: C1=C(C=C(C(=C1CO)O)Cl)O

3-Chlorogentisyl alcohol is a potent E. coli β-glucuronidase inhibitor with an IC50 value of 0.74 μM, an Ki value of 0.58 μM. 3-Chlorogentisyl alcohol shows antiproliferative activity. 3-Chlorogentisyl alcohol has the potential for the research of anti-cancer and anti-inflammatory therapies[1].
3-Chlorogentisyl alcohol (compound 1) (20 µM; 24 h) shows antiproliferative activity in Namalwa, U266 cells[1].

Reference

[1]. YichaoGe， et al. Exploring gabosine and chlorogentisyl alcohol derivatives from a marine-derived fungus as EcGUS inhibitors with informatic assisted approaches. European Journal of Medicinal Chemistry, 2022, 114699.