For research use only. Not for therapeutic Use.
3-Deazaadenosine hydrochloride（Cat No.:I019722）is a potent adenosine analog widely used in biochemical and pharmaceutical research. It inhibits S-adenosylhomocysteine (SAH) hydrolase, leading to the modulation of methylation processes, which are critical in gene expression and cellular signaling. This compound is a valuable tool for studying methylation-dependent pathways and epigenetic regulation. Additionally, it is explored for its potential antiviral, anticancer, and immunomodulatory effects. With its high specificity and stability, 3-Deazaadenosine hydrochloride supports advanced research in enzymology, drug development, and the molecular mechanisms of disease.
| Catalog Number | I019722 |
| CAS Number | 86583-19-9 |
| Molecular Formula | C₁₁H₁₅ClN₄O₄ |
| Purity | ≥95% |
| Target | HIV |
| IUPAC Name | (2R,3R,4S,5R)-2-(4-aminoimidazo[4,5-c]pyridin-1-yl)-5-(hydroxymethyl)oxolane-3,4-diol;hydrochloride |
| InChI | InChI=1S/C11H14N4O4.ClH/c12-10-7-5(1-2-13-10)15(4-14-7)11-9(18)8(17)6(3-16)19-11;/h1-2,4,6,8-9,11,16-18H,3H2,(H2,12,13);1H/t6-,8-,9-,11-;/m1./s1 |
| InChIKey | WQRKYGAAEYXMKZ-RPWKAPHTSA-N |
| SMILES | C1=CN=C(C2=C1N(C=N2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O)N.Cl |
| Reference | [1]. Gordon RK, et al. Anti-HIV-1 activity of 3-deaza-adenosine analogs. Inhibition of S-adenosylhomocysteine hydrolase and nucleotide congeners. Eur J Biochem. 2003 Sep;270(17):3507-17.<br>[2]. Jeong SY, et al. 3-deazaadenosine, a S-adenosylhomocysteine hydrolase inhibitor, has dual effects on NF-kappaB regulation. Inhibition of NF-kappaB transcriptional activity and promotion of IkappaBalpha degradation. J Biol Chem. 1999 Jul 2;274(27):18981-8.<br>[3]. Sedding DG, et al. 3-Deazaadenosine prevents smooth muscle cell proliferation and neointima formation by interfering with Ras signaling. Circ Res. 2009 May 22;104(10):1192-200. |
