3-Demethyl Colchicine

• CAT Number: R047688
• CAS Number: 7336-33-6
• Molecular Formula: C21H23NO6
• Molecular Weight: 385.416
• Purity: ≥95%
• Synonyms: N-[(7S)-5,6,7,9-Tetrahydro-3-hydroxy-1,2,10-trimethoxy-9-oxobenzo[a]heptalen-7-yl]-acetamide; O3-Demethylcolchicine; 3-Demethyl-(-)-colchicine; 3-Demethylcolchicine; 3-Desmethylcolchicine; O3-Demethylcolchicine
• Target: NF-κB
• Storage: -20°C
• IUPAC Name: N-[(7S)-3-hydroxy-1,2,10-trimethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide
• InChI: InChI=1S/C21H23NO6/c1-11(23)22-15-7-5-12-9-17(25)20(27-3)21(28-4)19(12)13-6-8-18(26-2)16(24)10-14(13)15/h6,8-10,15,25H,5,7H2,1-4H3,(H,22,23)/t15-/m0/s1
• InChIKey: JRRUSQGIRBEMRN-HNNXBMFYSA-N
• SMILES: CC(=O)NC1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)OC)OC)OC)O

3-Demethyl colchicine is a derivative of colchicine, a natural alkaloid derived from the autumn crocus (Colchicum autumnale). This compound lacks a methyl group at the 3-position of the colchicine molecule. Colchicine and its derivatives are renowned for their anti-inflammatory and antimitotic properties, making them valuable in treating gout, familial Mediterranean fever, and certain cancers. Research on 3-demethyl colchicine explores its pharmacological activity, efficacy, and potential applications in various medical conditions.