3-Desacetyl Cefotaxime

• CAT Number: R050834
• CAS Number: 66340-28-1
• Molecular Formula: C₁₄H₁₅N₅O₆S₂
• Molecular Weight: 413.43
• Purity: ≥95%
• Synonyms: (6R,7R)-7-[[(2Z)-2-(2-Amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid; Deacetylcefotaxime; Desacetylcefotaxime
• Target: Bacterial
• Storage: -20°C
• IUPAC Name: (6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• InChI: InChI=1S/C14H15N5O6S2/c1-25-18-7(6-4-27-14(15)16-6)10(21)17-8-11(22)19-9(13(23)24)5(2-20)3-26-12(8)19/h4,8,12,20H,2-3H2,1H3,(H2,15,16)(H,17,21)(H,23,24)/b18-7-/t8-,12-/m1/s1
• InChIKey: FHYWAOQGXIZAAF-GHXIOONMSA-N
• SMILES: CO/N=C(/C1=CSC(=N1)N)\C(=O)N[C@H]2[C@@H]3N(C2=O)C(=C(CS3)CO)C(=O)O

3-Desacetyl Cefotaxime（Cat No.:R050834）is a primary metabolite of the third-generation cephalosporin antibiotic cefotaxime, formed in the liver. It retains significant antibacterial activity, especially against Gram-negative bacteria, by disrupting cell wall synthesis and leading to cell lysis. While cefotaxime is used clinically for severe infections like pneumonia, septicemia, and meningitis, 3-Desacetyl Cefotaxime is valuable in pharmacokinetic and pharmacodynamic studies to understand cefotaxime’s metabolism, efficacy, and safety profile. Research on this metabolite helps in assessing drug interactions and optimizing dosing in antibiotic therapy.