3-Desmethyl Gatifloxacin

• CAT Number: R056473
• CAS Number: 112811-57-1
• Molecular Formula: C18H20FN3O4
• Molecular Weight: 361.373
• Purity: ≥95%
• Synonyms: 1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic Acid; AM 1147; PD 135042; Gatifloxacin Impurity D
• Storage: Store at -20°C
• IUPAC Name: 1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid
• InChI: InChI=1S/C18H20FN3O4/c1-26-17-14-11(8-13(19)15(17)21-6-4-20-5-7-21)16(23)12(18(24)25)9-22(14)10-2-3-10/h8-10,20H,2-7H2,1H3,(H,24,25)
• InChIKey: XJCSNIFKGXSDGN-UHFFFAOYSA-N
• SMILES: COC1=C2C(=CC(=C1N3CCNCC3)F)C(=O)C(=CN2C4CC4)C(=O)O

3-Desmethyl Gatifloxacin is a fluoroquinolone antibiotic derivative of gatifloxacin, characterized by the absence of a methyl group at the 3-position of its quinolone ring. This modification influences its pharmacological properties and spectrum of activity. Like its parent compound, 3-desmethyl gatifloxacin retains antibacterial efficacy against a range of Gram-positive and Gram-negative bacteria by inhibiting bacterial DNA gyrase and topoisomerase IV, essential enzymes for bacterial DNA replication. Research into this compound explores its potential therapeutic applications and pharmacokinetic profile, particularly in treating respiratory and urinary tract infections, while also investigating its role in overcoming bacterial resistance to existing antibiotics.