3-Fluoromethcathinone

• CAT Number: I020881
• CAS Number: 1049677-77-1
• Molecular Formula: C10H12FNO
• Molecular Weight: 181.21
• Purity: 98%
• Synonyms: 3-Fluoromethcathinone; 3'-Fluoromethcathinone; 3-FMC
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 1-(3-fluorophenyl)-2-(methylamino)propan-1-one
• InChI: InChI=1S/C10H12FNO/c1-7(12-2)10(13)8-4-3-5-9(11)6-8/h3-7,12H,1-2H3
• InChIKey: PQIBROLLUQSNQI-UHFFFAOYSA-N
• SMILES: CNC(C)C(=O)c1cccc(F)c1

3-Fluoroomethcathinone (Cat. No: I020881) is a structural isomer of haloperidone, which can be used as a pharmaceutical organic intermediate for drug preparation in the fine chemical industry, mainly for scientific research.

Reference

1: Siedlecka-Kroplewska K, Wrońska A, Stasiłojć G, Kmieć Z. The Designer Drug 3-Fluoromethcathinone Induces Oxidative Stress and Activates Autophagy in HT22 Neuronal Cells. Neurotox Res. 2018 Oct;34(3):388-400. doi: 10.1007/s12640-018-9898-y. Epub 2018 Apr 14. PubMed PMID: 29656349.
2: Glicksberg L, Kerrigan S. Stability of Synthetic Cathinones in Urine. J Anal Toxicol. 2018 Mar 1;42(2):77-87. doi: 10.1093/jat/bkx091. PubMed PMID: 29194549.
3: Glicksberg L, Kerrigan S. Stability of Synthetic Cathinones in Blood. J Anal Toxicol. 2017 Nov 1;41(9):711-719. doi: 10.1093/jat/bkx071. PubMed PMID: 28977581.
4: Glicksberg L, Bryand K, Kerrigan S. Identification and quantification of synthetic cathinones in blood and urine using liquid chromatography-quadrupole/time of flight (LC-Q/TOF) mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Nov 1;1035:91-103. doi: 10.1016/j.jchromb.2016.09.027. Epub 2016 Sep 20. PubMed PMID: 27697731.
5: Odoardi S, Romolo FS, Strano-Rossi S. A snapshot on NPS in Italy: Distribution of drugs in seized materials analysed in an Italian forensic laboratory in the period 2013-2015. Forensic Sci Int. 2016 Aug;265:116-20. doi: 10.1016/j.forsciint.2016.01.037. Epub 2016 Feb 1. PubMed PMID: 26874736.
6: Gatch MB, Rutledge MA, Forster MJ. Discriminative and locomotor effects of five synthetic cathinones in rats and mice. Psychopharmacology (Berl). 2015 Apr;232(7):1197-205. doi: 10.1007/s00213-014-3755-3. Epub 2014 Oct 5. PubMed PMID: 25281225; PubMed Central PMCID: PMC4361374.
7: Siedlecka-Kroplewska K, Szczerba A, Lipinska A, Slebioda T, Kmiec Z. 3-Fluoromethcathinone, a structural analog of mephedrone, inhibits growth and induces cell cycle arrest in HT22 mouse hippocampal cells. J Physiol Pharmacol. 2014 Apr;65(2):241-6. PubMed PMID: 24781733.
8: Simmler LD, Rickli A, Hoener MC, Liechti ME. Monoamine transporter and receptor interaction profiles of a new series of designer cathinones. Neuropharmacology. 2014 Apr;79:152-60. doi: 10.1016/j.neuropharm.2013.11.008. Epub 2013 Nov 22. PubMed PMID: 24275046.
9: Al-Saffar Y, Stephanson NN, Beck O. Multicomponent LC-MS/MS screening method for detection of new psychoactive drugs, legal highs, in urine-experience from the Swedish population. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Jul 1;930:112-20. doi: 10.1016/j.jchromb.2013.04.043. Epub 2013 May 7. PubMed PMID: 23727875.
10: Marinetti LJ, Antonides HM. Analysis of synthetic cathinones commonly found in bath salts in human performance and postmortem toxicology: method development, drug distribution and interpretation of results. J Anal Toxicol. 2013 Apr;37(3):135-46. doi: 10.1093/jat/bks136. Epub 2013 Jan 29. PubMed PMID: 23361867.
11: Marusich JA, Grant KR, Blough BE, Wiley JL. Effects of synthetic cathinones contained in “bath salts” on motor behavior and a functional observational battery in mice. Neurotoxicology. 2012 Oct;33(5):1305-13. doi: 10.1016/j.neuro.2012.08.003. Epub 2012 Aug 23. PubMed PMID: 22922498; PubMed Central PMCID: PMC3475178.
12: Meyer MR, Vollmar C, Schwaninger AE, Wolf E, Maurer HH. New cathinone-derived designer drugs 3-bromomethcathinone and 3-fluoromethcathinone: studies on their metabolism in rat urine and human liver microsomes using GC-MS and LC-high-resolution MS and their detectability in urine. J Mass Spectrom. 2012 Feb;47(2):253-62. doi: 10.1002/jms.2960. PubMed PMID: 22359337.
13: Davis S, Rands-Trevor K, Boyd S, Edirisinghe M. The characterisation of two halogenated cathinone analogues: 3,5-difluoromethcathinone and 3,5-dichloromethcathinone. Forensic Sci Int. 2012 Apr 10;217(1-3):139-45. doi: 10.1016/j.forsciint.2011.10.042. Epub 2011 Nov 15. PubMed PMID: 22088945.
14: Pawlik E, Plässer G, Mahler H, Daldrup T. Studies on the phase I metabolism of the new designer drug 3-fluoromethcathinone using rabbit liver slices. Int J Legal Med. 2012 Mar;126(2):231-40. doi: 10.1007/s00414-011-0601-6. Epub 2011 Jul 23. Erratum in: Int J Legal Med. 2012 Mar;126(2):241-2. PubMed PMID: 21785905.
15: Archer RP. Fluoromethcathinone, a new substance of abuse. Forensic Sci Int. 2009 Mar 10;185(1-3):10-20. doi: 10.1016/j.forsciint.2008.11.013. Epub 2009 Feb 4. PubMed PMID: 19195800.