3-Hydroxy Nevirapine

• CAT Number: R013062
• CAS Number: 174532-82-2
• Molecular Formula: C15H14N4O2
• Molecular Weight: 282.30
• Purity: 98%
• Synonyms: 11-Cyclopropyl-5,11-dihydro-3-hydroxy-4-methy-6H-dipyrido[3,2-b:2’,3’-e][1,4]diazepin-6-one
• Appearance: Off-White to Pale Yellow Solid
• Storage: Store at RT
• IUPAC Name: 2-cyclopropyl-6-hydroxy-7-methyl-2,4,9,15-tetrazatricyclo[9.4.0.03,8]pentadeca-1(11),3,5,7,12,14-hexaen-10-one
• InChI: InChI=1S/C15H14N4O2/c1-8-11(20)7-17-14-12(8)18-15(21)10-3-2-6-16-13(10)19(14)9-4-5-9/h2-3,6-7,9,20H,4-5H2,1H3,(H,18,21)
• InChIKey: DANIONWINZEYME-UHFFFAOYSA-N
• SMILES: CC1=C2C(=NC=C1O)N(C3=C(C=CC=N3)C(=O)N2)C4CC4

3-Hydroxy Nevirapine(CAT: R013062) is a metabolite of Nevirapine, an antiretroviral drug used in the treatment of HIV-1 infection. Nevirapine belongs to the class of non-nucleoside reverse transcriptase inhibitors (NNRTIs), which function by blocking the reverse transcriptase enzyme, essential for HIV replication. The 3-hydroxy metabolite is formed during the drug’s metabolism in the liver, primarily by the action of cytochrome P450 enzymes. While Nevirapine is effective in suppressing viral replication, its metabolites, including 3-Hydroxy Nevirapine, are of interest in pharmacokinetics and toxicity studies, as they may contribute to side effects like hepatotoxicity and skin reactions.