3'-Hydroxypterostilbene

• CAT Number: I018415
• CAS Number: 475231-21-1
• Molecular Formula: C₁₆H₁₆O₄
• Molecular Weight: 272.30
• Purity: ≥95%
• Target: Autophagy
• Storage: 2-8°C
• IUPAC Name: 4-[(E)-2-(3,5-dimethoxyphenyl)ethenyl]benzene-1,2-diol
• InChI: InChI=1S/C16H16O4/c1-19-13-7-12(8-14(10-13)20-2)4-3-11-5-6-15(17)16(18)9-11/h3-10,17-18H,1-2H3/b4-3+
• InChIKey: UQRBFXIUUDJHSN-ONEGZZNKSA-N
• SMILES: COC1=CC(=CC(=C1)C=CC2=CC(=C(C=C2)O)O)OC

3′-Hydroxypterostilbene (Cat No.:475231-21-1), one of the active ingredients in horse bean and rosewood heart, may be effective in treating different types of hematologic malignancies. 3′-Hydroxypterostilbene can effectively inhibit the growth of human colon cancer cells by inducing apoptosis and autophagy, with IC50 values of 9.0µM, 40.2µM and 70.9µM for COLO205, HCT-116 and HT-29 cells, respectively. 3′-Hydroxypterostilbene can inhibit the p70S6K and p38MAPK signaling pathways in the PI3K/Akt/mTOR signaling pathway, and activate the ERK1/2, JNK1/2 signaling pathways.