3-Indolepropionic Acid

• CAT Number: R060347
• CAS Number: 830-96-6
• Molecular Formula: C11H11NO2
• Molecular Weight: 189.214
• Purity: ≥95%
• Synonyms: 1H-Indole-3-propanoic Acid; Indole-3-propionic Acid; 1H-Indole-3-propionic Acid; 3-(1H-Indol-3-yl)propanoic Acid; 3-(1H-Indol-3-yl)propionic Acid; 3-(2-Carboxyethyl)-1H-indole; 3-(3-Indolyl)propanoic Acid; 3-(3-Indolyl)propionic Acid; 3-(Indole-3-yl)
• Target: NF-κB
• Storage: Store at RT
• IUPAC Name: 3-(1H-indol-3-yl)propanoic acid
• InChI: InChI=1S/C11H11NO2/c13-11(14)6-5-8-7-12-10-4-2-1-3-9(8)10/h1-4,7,12H,5-6H2,(H,13,14)
• InChIKey: GOLXRNDWAUTYKT-UHFFFAOYSA-N
• SMILES: C1=CC=C2C(=C1)C(=CN2)CCC(=O)O

Indole-3-propionic acid, also known as IPA and SHP-622, is a beta-amyloid protein neurotoxicity inhibitor potentially for the treatment of Friedreich/’s ataxia. The administration of IPA significantly decreased the level of 4-hydroxy-2-nonenal, a marker of lipid peroxidation, in ischemic hippocampal homogenates compared with that in the vehicle-treated ischemic groups at various times after ischemia/reperfusion. In addition, immunostaining for 8-hydroxy-2/’-deoxyguanosine showed DNA damage in pyramidal neurons in the ischemic CA1 was significantly lower in the IPA-treated ischemic groups than in the vehicle-treated ischemic groups. IPA may be used as a pharmacological agent to protect against iron-induced oxidative damage to membranes and, potentially, against carcinogenesis.

Reference

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