3-Indoxyl Sulfate Potassium Salt

• CAT Number: R053500
• CAS Number: 2642-37-7
• Molecular Formula: C8H6KNO4S
• Molecular Weight: 251.297
• Purity: ≥95%
• Synonyms: 1H-Indol-3-ol 3-(Hydrogen Sulfate) Potassium Salt; 1H-Indol-3-ol Hydrogen Sulfate (Ester) Monopotassium Salt; Indol-3-yl Potassium Sulfate; Indol-3-ol Potassium Sulfate; Indol-3-yl Sulfate Potassium Salt; Potassium Indol-3-yl Sulfate
• Target: Endogenous Metabolite
• Storage: -20°C
• IUPAC Name: potassium;1H-indol-3-yl sulfate
• InChI: InChI=1S/C8H7NO4S.K/c10-14(11,12)13-8-5-9-7-4-2-1-3-6(7)8;/h1-5,9H,(H,10,11,12);/q;+1/p-1
• InChIKey: MDAWATNFDJIBBD-UHFFFAOYSA-M
• SMILES: C1=CC=C2C(=C1)C(=CN2)OS(=O)(=O)[O-].[K+]

Indoxyl sulfate is a metabolite of tryptophan derived from dietary protein. Tryptophan is metabolized by intestinal bacteria into indole, which is absorbed into the blood and then further metabolized to indoxyl sulfate in the liver, which is normally excreted in urine. In chronic kidney disease patients where renal function is compromised, indoxyl sulfate can accumulate in serum as a uremic toxin, inducing oxidative stress and accelerating progression of the disease. Indoxyl sulfate at 250 µM can induce the activation of NF-κB, promoting the expression of both TGF-β1 and Smad3 expression in proximal tubular cells of rats, which is associated with profibrotic activity.