3-MeOARh-NTR

• CAT Number: I041371
• Molecular Formula: C33H30N3O8+
• Molecular Weight: 596.61
• Purity: ≥95%
• Synonyms: [9-(2-carboxyphenyl)-7-methoxy-6-[(4-nitrophenyl)methoxycarbonylamino]xanthen-3-ylidene]-diethylazanium
• InChI: InChI=1S/C33H29N3O8/c1-4-35(5-2)22-14-15-25-28(16-22)44-29-18-27(34-33(39)43-19-20-10-12-21(13-11-20)36(40)41)30(42-3)17-26(29)31(25)23-8-6-7-9-24(23)32(37)38/h6-18H,4-5,19H2,1-3H3,(H,37,38)/p+1
• InChIKey: DIXSWIOVQOAGAZ-UHFFFAOYSA-O
• SMILES: CC[N+](=C1C=CC2=C(C3=CC(=C(C=C3OC2=C1)NC(=O)OCC4=CC=C(C=C4)[N+](=O)[O-])OC)C5=CC=CC=C5C(=O)O)CC

3-MeOARh-NTR is an activatable imaging probe with high selectivity, and good stability. 3-MeOARh-NTR possesses high selectivity and high signal-to-noise ratio for nitroreductase (NTR) detection, and serves as an efficient molecular tool for endogenous NTR detection[1].
3-MeOARh-NTR (10 μM, 30 min; cell incubated with 20% O2 and 10% O2 for 12 h) produces a strong fluorescence signal in living HeLa cells with decreasing oxygen contents[1].3-MeOARh-NTR (10 μM, 30 min) produces fluorescence imaging of kidney tissues from mice with λex = 488 nm and λem=510-590 nm. Thus, 3-MeOARh-NTR is a efficient probe to evaluate kidney hypoxia by NTR detection[1].

Reference

[1]. Guo H, et al. Designing a Brightness-Restored Rhodamine Derivative by the Ortho-Compensation Effect for Assessing Drug-Induced Acute Kidney Injury. Anal Chem. 2023 May 2;95(17):6863-6870.
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