3-Mercaptopropionic acid NHS ester

For research use only. Not for therapeutic Use.

  • CAT Number: I015251
  • CAS Number: 117235-10-6
  • Molecular Formula: C₇H₉NO₄S
  • Molecular Weight: 203.22
  • Purity: ≥95%
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3-Mercaptopropionic acid NHS ester(CAT: I015251) operates as an alkyl/ether-based linker for constructing PROTACs (PROteolysis Targeting Chimeras). Within the architecture of PROTACs, this linker enables the coupling of two distinct ligands—one designed for an E3 ubiquitin ligase, and the other tailored for the target protein. This strategic connection capitalizes on the intracellular ubiquitin-proteasome system, orchestrating the targeted degradation of specific proteins.


Catalog Number I015251
CAS Number 117235-10-6
Molecular Formula C₇H₉NO₄S
Purity ≥95%
Target PROTAC Linkers
Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

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