3-Methoxy Loratadine-d4

• CAT Number: R010179
• CAS Number: 1189501-87-8
• Molecular Formula: C23H25ClN2O3
• Molecular Weight: 416.938
• Purity: ≥95%
• Synonyms: 4-(8-Chloro-5,6-dihydro-3-methoxy-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidine-d4-carboxylic Acid Ethyl Ester
• Storage: Store at -20℃
• IUPAC Name: ethyl 4-(8-chloro-3-methoxy-5,6-dihydrobenzo[1,2]cyclohepta[2,4-b]pyridin-11-ylidene)-2,2,6,6-tetradeuteriopiperidine-1-carboxylate
• InChI: InChI=1S/C23H25ClN2O3/c1-3-29-23(27)26-10-8-15(9-11-26)21-20-7-6-18(24)12-16(20)4-5-17-13-19(28-2)14-25-22(17)21/h6-7,12-14H,3-5,8-11H2,1-2H3/i10D2,11D2
• InChIKey: XIUQXOBEGLVYPC-MKQHWYKPSA-N
• SMILES: CCOC(=O)N1CCC(=C2C3=C(CCC4=CC(=CN=C42)OC)C=C(C=C3)Cl)CC1

3-Methoxy Loratadine-d4 is a deuterated form of 3-Methoxy Loratadine, an analog of the antihistamine drug loratadine, commonly used to treat allergies. In this compound, four hydrogen atoms are replaced with deuterium, enhancing its utility in pharmacokinetic and metabolic studies. The deuterium labeling allows for precise tracking and analysis using mass spectrometry and NMR spectroscopy. Despite the isotopic substitution, 3-Methoxy Loratadine-d4 retains the same pharmacological properties as the non-deuterated version, making it valuable for research into drug metabolism, distribution, and excretion.