3-Methyl-L-histidine-d3 hydrochloride

• CAT Number: I040193
• Molecular Formula: C7H9D3ClN3O2
• Molecular Weight: 208.66
• Purity: ≥95%
• Synonyms: (2S)-2-amino-3-[3-(trideuteriomethyl)imidazol-4-yl]propanoic acid;hydrochloride
• InChI: InChI=1S/C7H11N3O2.ClH/c1-10-4-9-3-5(10)2-6(8)7(11)12;/h3-4,6H,2,8H2,1H3,(H,11,12);1H/t6-;/m0./s1/i1D3
• InChIKey: VWCFOWBWRITCRS-UPBCFZPRSA-N
• SMILES: CN1C=NC=C1CC(C(=O)O)N.Cl

3-Methyl-L-histidine-d3 hydrochloride (Cat No.: I040193) is a deuterated form of 3-methyl-L-histidine, an amino acid derivative commonly found in skeletal muscle proteins. The deuterium (d3) substitution at the methyl group allows for its use in metabolic and biochemical research, particularly in isotope labeling studies. This compound is often utilized in studies examining muscle protein turnover, metabolism, and histidine-related pathways. Its stable isotope labeling enables precise tracking and quantification of its incorporation in protein synthesis or degradation studies.

Reference

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
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[2]. White WJ, Lawrie RA. Variations in the levels of 3-methyl-l-histidine of the myosins within the bovine carcass. Meat Sci. 1985;15(3):173-81.
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