3-Methyl-L-histidine-d3 hydrochloride

• CAT Number: I040193
• Molecular Formula: C7H9D3ClN3O2
• Molecular Weight: 208.66
• Purity: ≥95%
• Synonyms: (2S)-2-amino-3-[3-(trideuteriomethyl)imidazol-4-yl]propanoic acid;hydrochloride
• InChI: InChI=1S/C7H11N3O2.ClH/c1-10-4-9-3-5(10)2-6(8)7(11)12;/h3-4,6H,2,8H2,1H3,(H,11,12);1H/t6-;/m0./s1/i1D3
• InChIKey: VWCFOWBWRITCRS-UPBCFZPRSA-N
• SMILES: CN1C=NC=C1CC(C(=O)O)N.Cl

3-Methyl-L-histidine-d3 hydrochloride is the deuterium labeled 3-Methyl-L-histidine hydrochloride. 3-Methyl-L-histidine hydrochloride can be found in actin and myosin and is a derivative of histidine[1][2].
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Reference

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
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[2]. White WJ, Lawrie RA. Variations in the levels of 3-methyl-l-histidine of the myosins within the bovine carcass. Meat Sci. 1985;15(3):173-81.
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