3-O-Decyclopropyl Roflumilast

• CAT Number: R056993
• CAS Number: 1391052-76-8
• Molecular Formula: C13H8Cl2F2N2O3
• Molecular Weight: 349.115
• Purity: ≥95%
• Synonyms: 3-(Hydroxy)-N-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy)benzamide
• Target: Phosphodiesterase (PDE)
• Storage: -20°C
• IUPAC Name: N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)-3-hydroxybenzamide
• InChI: InChI=1S/C13H8Cl2F2N2O3/c14-7-4-18-5-8(15)11(7)19-12(21)6-1-2-10(9(20)3-6)22-13(16)17/h1-5,13,20H,(H,18,19,21)
• InChIKey: GZHTYXYJBZYTEV-UHFFFAOYSA-N
• SMILES: C1=CC(=C(C=C1C(=O)NC2=C(C=NC=C2Cl)Cl)O)OC(F)F

3-O-Decyclopropyl Roflumilast (CAS 1391052-76-8) is the impurity of Roflumilast, which is a selective and long-acting inhibitor of PDE-4 with IC50 value of 0.8 nM. Due to its selective inhibition of the PDE4 isoenzyme in lung cells, roflumilast is indicated for the management of chronic obstrtuctive pulmonary disease (COPD) exacerbations.

Reference

1.Calverley, Peter MA, et al. "Effect of 1-year treatment with roflumilast in severe chronic obstructive pulmonary disease." American journal of respiratory and critical care medicine 176.2 (2007): 154-161.
2.Calverley, Peter MA, et al. "Roflumilast in symptomatic chronic obstructive pulmonary disease: two randomised clinical trials." The Lancet 374.9691 (2009): 685-694.
3.Fabbri, Leonardo M., et al. "Roflumilast in moderate-to-severe chronic obstructive pulmonary disease treated with longacting bronchodilators: two randomised clinical trials." The Lancet 374.9691 (2009): 695-703.