3'-O-(t-butyldimethylsilyl)thymidine

• CAT Number: L022145
• CAS Number: 40733-27-5
• Molecular Formula: C16H28N2O5Si
• Molecular Weight: 356.49
• Purity: ≥95%
• Target: Nucleoside Antimetabolite/Analog
• IUPAC Name: 1-[(2R,4S,5R)-4-[tert-butyl(dimethyl)silyl]oxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione
• InChI: InChI=1S/C16H28N2O5Si/c1-10-8-18(15(21)17-14(10)20)13-7-11(12(9-19)22-13)23-24(5,6)16(2,3)4/h8,11-13,19H,7,9H2,1-6H3,(H,17,20,21)/t11-,12+,13+/m0/s1
• InChIKey: QAPSNMNOIOSXSQ-YNEHKIRRSA-N
• SMILES: CC1=CN(C(=O)NC1=O)[C@H]2C[C@@H]([C@H](O2)CO)O[Si](C)(C)C(C)(C)C

3′-O-(t-butyldimethylsilyl)thymidine（Cat No.:L022145）is a thymidine derivative in which a t-butyldimethylsilyl (TBDMS) group is attached to the 3′ hydroxyl group of the thymidine sugar. This silylation protects the hydroxyl group during synthetic reactions, preventing unwanted side reactions, and is commonly used in the preparation of nucleoside analogs. The TBDMS group is easily removable under mild acidic conditions, allowing for selective deprotection in the synthesis of nucleic acids or other modified nucleotides. This compound is useful in nucleoside chemistry, particularly in the synthesis of modified DNA or RNA for research and therapeutic purposes.