3-Phosphoglyceric acid

• CAT Number: I045969
• CAS Number: 820-11-1
• Molecular Formula: C3H7O7P
• Molecular Weight: 186.06
• Purity: ≥95%
• Synonyms: 2-hydroxy-3-phosphonooxypropanoic acid
• InChI: InChI=1S/C3H7O7P/c4-2(3(5)6)1-10-11(7,8)9/h2,4H,1H2,(H,5,6)(H2,7,8,9)
• InChIKey: OSJPPGNTCRNQQC-UHFFFAOYSA-N
• SMILES: C(C(C(=O)O)O)OP(=O)(O)O

3-Phosphoglyceric acid is a metabolic intermediate in both glycolysis and the Calvin cycle. 3-Phosphoglyceric acid is involved in alveolar macrophage epigenetic regulation.
3-Phosphoglyceric acid (400 µM; 24 hours; BMDMs) treatment enhances Spp1 transcription in VHL-deficient macrophages, and the reduced H3K4me3 modification is also reversed[1].
3-Phosphoglyceric treatment significantly augmentes gene expression as well as H3K4me3 deposition of Spp1 in IL-4-stimulated macrophages[1].
In yeast, 3-Phosphoglyceric acid acts as a metabolic checkpoint for the formation of a multicomponent enzyme complex including serine metabolic enzymes and pyruvate kinase isoform 2 (PKM2) homologue, which senses both serine metabolism and glycolysis and regulates H3K4 methylation and histone phosphorylation[1].

Reference

[1]. Zhang W, et al. The E3 ligase VHL controls alveolar macrophage function via metabolic-epigenetic regulation. J Exp Med. 2018 Dec 3;215(12):3180-3193.
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