For research use only. Not for therapeutic Use.
3,3′-Difluorobenzaldazine (DFB) is a selective positive allosteric modulator of mGluR5. 3,3′-Difluorobenzaldazine potentiates 3- to 6-fold action for mGlu5 agonists (Glutamate, Quisqualate, and 3,5-Dihydroxyphenylglycine), with EC50s in the 2 to 5 μM range[1].
3,3′-Difluorobenzaldazine (DFB) causes a concentration-dependent potentiation of the response of human mGluR5 CHO cells to 300 nM glutamate in this assay. The maximal potentiation at this concentration of glutamate is approximately 3.1-fold, with an EC50 for potentiation of 2.6 μM. 3,3′-Difluorobenzaldazine causes similar potentiation of the responses of both human mGluR5 and rat mGluR5 CHO cells to glutamate, quisqualate, and DHPG with comparable potencies[1].
3,3′-Difluorobenzaldazine (40-100 nmol; icv) attenuates the locomotor hyperactivity, motor incoordination, and cognitive impairment induced by Ketamine[2].
| Catalog Number | M073939 |
| CAS Number | 15332-10-2 |
| Synonyms | (E)-1-(3-fluorophenyl)-N-[(E)-(3-fluorophenyl)methylideneamino]methanimine |
| Molecular Formula | C14H10F2N2 |
| Purity | ≥95% |
| InChI | InChI=1S/C14H10F2N2/c15-13-5-1-3-11(7-13)9-17-18-10-12-4-2-6-14(16)8-12/h1-10H/b17-9+,18-10+ |
| InChIKey | YYMCVDNIIFNDJK-BEQMOXJMSA-N |
| SMILES | C1=CC(=CC(=C1)F)C=NN=CC2=CC(=CC=C2)F |
| Reference | [1]. O’Brien JA, et al, Chen TB, et al. A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5. Mol Pharmacol. 2003;64(3):731-740. [2]. Chan MH, et al. Attenuation of ketamine-evoked behavioral responses by mGluR5 positive modulators in mice. Psychopharmacology (Berl). 2008 May;198(1):141-8. |
