3,3'-Diindolylmethane

• CAT Number: I000023
• CAS Number: 1968-05-4
• Molecular Formula: C17H14N2
• Molecular Weight: 246.3
• Purity: ≥95%
• Synonyms: 3-(1H-indol-3-ylmethyl)-1H-indole
• Target: Apoptosis Inducers
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IC50: 65 uM (SKOV-3 cell, 72h)
• InChIKey: VFTRKSBEFQDZKX-UHFFFAOYSA-N

3,3′-Diindolylmethane (DIM)(CAT: I000023) is a compound derived from the digestion of indole-3-carbinol, which is found in cruciferous vegetables such as broccoli, cauliflower, and cabbage. DIM has gained attention for its potential health benefits, particularly its anti-cancer properties. It has been shown to inhibit the growth of various cancer cells, including breast, prostate, and colon cancer cells, by regulating cell cycle progression, inducing apoptosis, and inhibiting angiogenesis. DIM also exhibits anti-inflammatory and antioxidant effects, which contribute to its overall protective effects against cancer and other chronic diseases. Additionally, DIM has been investigated for its potential benefits in hormonal balance and as a modulator of estrogen metabolism.

Reference

[1]. Prabodh K, et al. Activation of Checkpoint Kinase 2 by 3,3-Diindolylmethane Is Required for Causing G2/M Cell Cycle Arrest in Human Ovarian Cancer Cells. Mol Pharmacol 78:297-309, 2010 


[2]. Fan S, et al. DIM (3,3/’-diindolylmethane) confers protection against ionizing radiation by a unique mechanism. Proc Natl Acad Sci U S A. 2013 Oct 14. 


[3]. Poornima J, et al. Regulation of carbohydrate metabolism by indole-3-carbinol and its metabolite 3,3/’-diindolylmethane in high-fat diet-induced C57BL/6J mice. Mol Cell Biochem. 2013 Sep 27. 


[4]. Li XJ, et al. 3,3/’-Diindolylmethane suppresses the growth of gastric cancer cells via activation of the Hippo signaling pathway. Oncol Rep. 2013 Nov;30(5):2419-26. 


[5]. Kandala PK, et al. Blocking epidermal growth factor receptor activation by 3,3/’-diindolylmethane suppresses ovarian tumor growth in vitro and in vivo. J Pharmacol Exp Ther. 2012 Apr;341(1):24-32. 


[6]. Leibelt DA, et al. Evaluation of chronic dietary exposure to indole-3-carbinol and absorption-enhanced 3,3/’-diindolylmethane in sprague-dawley rats. Toxicol Sci. 2003 Jul;74(1):10-21.