For research use only. Not for therapeutic Use.
Triiodothyronine (Cat No.:R000993) is a biologically active thyroid hormone that plays a crucial role in regulating metabolism, growth, and development. It is produced primarily through peripheral conversion of thyroxine (T4) and acts by binding to nuclear thyroid hormone receptors, influencing gene expression. T3 increases basal metabolic rate, protein synthesis, and sensitivity to catecholamines. Clinically, it is used to treat hypothyroidism and certain thyroid-related disorders. Due to its potent physiological effects, precise dosing and monitoring are essential to avoid adverse effects.
| CAS Number | 6893-02-3 |
| Synonyms | O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine; Liothyronine; T3; L-T3;?3,3’,5-Triiodothyronine; T3 (Hormone); Tresitope; Triiodothyronine; |
| Molecular Formula | C15H12I3NO4 |
| Purity | ≥95% |
| Storage | Store at RT |
| IUPAC Name | (2S)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoic acid |
| InChI | InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 |
| InChIKey | AUYYCJSJGJYCDS-LBPRGKRZSA-N |
| SMILES | C1=CC(=C(C=C1OC2=C(C=C(C=C2I)CC(C(=O)O)N)I)I)O |
| Reference | </br>1:3, 3/’, 5-triiodo-L-thyronine Increases In Vitro Chondrogenesis of Mesenchymal Stem Cells From Human Umbilical Cord Stroma Through SRC2. Fernández-Pernas P, Fafián-Labora J, Lesende-Rodriguez I, Mateos J, De la Fuente A, Fuentes I, De Toro Santos J, Blanco García F, Arufe MC.J Cell Biochem. 2016 Sep;117(9):2097-108. doi: 10.1002/jcb.25515. Epub 2016 Mar 30. PMID: 26869487 </br>2:Anti-Apoptotic Effects of 3,3/’,5-Triiodo-L-Thyronine in the Liver of Brain-Dead Rats. Rebolledo RA, Van Erp AC, Ottens PJ, Wiersema-Buist J, Leuvenink HG, Romanque P.PLoS One. 2015 Oct 5;10(10):e0138749. doi: 10.1371/journal.pone.0138749. eCollection 2015. PMID: 26437380 Free PMC Article</br>3:Characterization of little skate (Leucoraja erinacea) recombinant transthyretin: Zinc-dependent 3,3/’,5-triiodo-l-thyronine binding. Suzuki S, Kasai K, Yamauchi K.Gen Comp Endocrinol. 2015 Jun-Jul;217-218:43-53. doi: 10.1016/j.ygcen.2015.04.006. Epub 2015 Apr 9. PMID: 25863347 </br>4:Monocrotophos pesticide decreases the plasma levels of total 3,3/’,5-triiodo-l-thyronine and alters the expression of genes associated with the thyroidal axis in female goldfish (Carassius auratus). Zhang X, Tian H, Wang W, Ru S.PLoS One. 2014 Sep 30;9(9):e108972. doi: 10.1371/journal.pone.0108972. eCollection 2014. PMID: 25268935 Free PMC Article</br>5:3,3/’,5-Triiodo-L-thyronine-like activity in effluents from domestic sewage treatment plants detected by in vitro and in vivo bioassays. Murata T, Yamauchi K.Toxicol Appl Pharmacol. 2008 Feb 1;226(3):309-17. Epub 2007 Sep 16. PMID: 17949767 </br>6:The influence of 3,3/’,5-triiodo-L-thyronine on human haematopoiesis. Grymuła K, Paczkowska E, Dziedziejko V, Baśkiewicz-Masiuk M, Kawa M, Baumert B, Celewicz Z, Gawrych E, Machaliński B.Cell Prolif. 2007 Jun;40(3):302-15. PMID: 17531076 </br>7:3,3/’,5-Triiodo-L-thyronine inhibits ductal pancreatic adenocarcinoma proliferation improving the cytotoxic effect of chemotherapy. Michienzi S, Bucci B, Verga Falzacappa C, Patriarca V, Stigliano A, Panacchia L, Brunetti E, Toscano V, Misiti S.J Endocrinol. 2007 May;193(2):209-23. PMID: 17470512 Free Article</br>8:Alterations in expression of senescence marker protein-30 gene by 3,3/’,5-triiodo-L-thyronine (T3). Sar P, Rath B, Subudhi U, Chainy GB, Supakar PC.Mol Cell Biochem. 2007 Sep;303(1-2):239-42. Epub 2007 Apr 11. PMID: 17426926 </br>9:3,3/’,5-Triiodo-L-thyronine up-regulation of Na,K-ATPase activity and cell surface expression in alveolar epithelial cells is Src kinase- and phosphoinositide 3-kinase-dependent. Lei J, Mariash CN, Ingbar DH.J Biol Chem. 2004 Nov 12;279(46):47589-600. Epub 2004 Aug 31. PMID: 15342623 Free Article</br>10:Determination of (+)-3,3/’,5-triiodo-L-thyronine (L-T3) from serum using a sequential injection analysis/immunosensor system. Stefan RI, van Staden JF, Aboul-Enein HY.J Immunoassay Immunochem. 2004;25(2):183-9. PMID: 15162921 |
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