For research use only. Not for therapeutic Use.
Local catabolism of the amino acid tryptophan by indoleamine 2,3-<wbr></wbr>dioxygenase (IDO) is considered an important mechanism of regulating T-<wbr></wbr>cell immunity. Inhibition of the production of T helper-<wbr></wbr>1 (TH1) cytokines offers a new strategy for treating TH1 mediated autoimmune diseases such as multiple sclerosis. 3,4-<wbr></wbr>DAA is an orally active synthetic derivative of the tryptophan metabolite anthranilic acid. It suppresses antigen-<wbr></wbr>specific proliferation of MBP Ac1-<wbr></wbr>11 TCR CD4
| Catalog Number | R019965 |
| Synonyms | 2-[3-(3,4-dimethoxy-phenyl)-acryloylamino]-3-hydroxy-benzoic acid |
| Molecular Formula | C18H17NO6 |
| Purity | ≥95% |
| Storage | -20°C |
| InChI | InChI=1S/C18H17NO6/c1-24-14-8-6-11(10-15(14)25-2)7-9-16(21)19-17-12(18(22)23)4-3-5-13(17)20/h3-10,20H,1-2H3,(H,19,21)(H,22,23)/b9-7+ |
| InChIKey | HUBVPPBIEOCMIE-VQHVLOKHSA-N |
| SMILES | COc1ccc(C=C/C(=O)Nc2c(O)cccc2C(=O)O)cc1OC |
| Reference | 1.Platten, M.,ho, P.P.,Youssef, S., et al. Treatment of autoimmune neuroinflammation with a synthetic tyrptophan metabolite. Science 310, 850-855 (2005). |
