3,4-Di-1H-indol-3-yl-1H-pyrrole-2,5-dione

• CAT Number: M027406
• CAS Number: 119139-23-0
• Molecular Formula: C20H13N3O2
• Molecular Weight: 327.34
• Purity: ≥95%
• Synonyms: 3,4-di-1H-indol-3-yl-1H-pyrrole-2,5-dione
• Target: TGF-beta/Smad
• Solubility: Soluble in DMSO
• Storage: Store at -20°C
• IUPAC Name: 3,4-bis(1H-indol-3-yl)pyrrole-2,5-dione
• InChI: InChI=1S/C20H13N3O2/c24-19-17(13-9-21-15-7-3-1-5-11(13)15)18(20(25)23-19)14-10-22-16-8-4-2-6-12(14)16/h1-10,21-22H,(H,23,24,25)
• InChIKey: DQYBRTASHMYDJG-UHFFFAOYSA-N
• SMILES: C1=CC=C2C(=C1)C(=CN2)C3=C(C(=O)NC3=O)C4=CNC5=CC=CC=C54

Bisindolylmaleimide IV（Cat No.:M027406）, also known as Arcyriarubin A, is a powerful inhibitor of protein kinase C (PKC) with an IC50 range of 0.1-0.55 μM. It also exhibits inhibitory activity against PKA, with an IC50 range of 3.1-11.8 μM. Furthermore, Bisindolylmaleimide IV demonstrates potent inhibition of human cytomegalovirus (HCMV) replication in cell culture, with an IC50 value of 0.2 μM. These properties make it a valuable compound for studying PKC and PKA signaling pathways and for exploring its potential as an antiviral agent against HCMV.