3,4-dihydroxy Hydrocinnamic acid (L-Aspartic acid dibenzyl ester) amide

• CAT Number: R010664
• CAS Number: 615264-62-5
• Molecular Formula: C27H27NO7
• Molecular Weight: 477.513
• Purity: ≥95%
• Synonyms: 3,4-dihydroxy Hydrocinnamic acid (L-Aspartic acid dibenzyl ester) amide
• Target: Acyltransferase
• Storage: -20°C
• IUPAC Name: dibenzyl (2S)-2-[3-(3,4-dihydroxyphenyl)propanoylamino]butanedioate
• InChI: InChI=1S/C27H27NO7/c29-23-13-11-19(15-24(23)30)12-14-25(31)28-22(27(33)35-18-21-9-5-2-6-10-21)16-26(32)34-17-20-7-3-1-4-8-20/h1-11,13,15,22,29-30H,12,14,16-18H2,(H,28,31)/t22-/m0/s1
• InChIKey: SNEUAEKNRYBOTP-QFIPXVFZSA-N
• SMILES: C1=CC=C(C=C1)COC(=O)CC(C(=O)OCC2=CC=CC=C2)NC(=O)CCC3=CC(=C(C=C3)O)O

Acyl-<wbr></wbr>coenzyme A: cholesterol acyltransferase-<wbr></wbr>1 and -<wbr></wbr>2 (ACAT-<wbr></wbr>1 and ACAT-<wbr></wbr>2) catalyze the formation of cholesterol esters from cholesterol and long chain fatty acyl-<wbr></wbr>coenzyme A, and may play a role in the development of atherosclerosis. CAY10485 inhibits human ACAT-<wbr></wbr>1 and ACAT-<wbr></wbr>2 with an IC50 values of 95 and 81 µM, respectively. It also inhibits copper-<wbr></wbr>mediated oxidation of low density lipoproteins by 91% at a concentration of 2 µM.

Reference

1.Rudel, L.L.,Lee, R.G., and Cockman, T.L. Acyl coenzyme A: Cholesterol acyltransferase types 1 and 2: structure and function in atherosclerosis. Current Opinion in Lipidology 12, 121-127 (2001).