3',4'-Dimethoxyflavone

• CAT Number: M224687
• CAS Number: 4143-62-8
• Molecular Formula: C17H14O4
• Molecular Weight: 282.29
• Purity: ≥95%
• Synonyms: 2-(3,4-dimethoxyphenyl)chromen-4-one
• InChI: InChI=1S/C17H14O4/c1-19-15-8-7-11(9-17(15)20-2)16-10-13(18)12-5-3-4-6-14(12)21-16/h3-10H,1-2H3
• InChIKey: ZGHORMOOTZTQFL-UHFFFAOYSA-N
• SMILES: COC1=C(C=C(C=C1)C2=CC(=O)C3=CC=CC=C3O2)OC

3′,4′-Dimethoxyflavone is a lipophilic flavone, can be isolated from the leaves of Primula veris. 3′,4′-Dimethoxyflavone can reduce the synthesis and accumulation of PARP and protect cortical neurones against cell death induced by Parthanatos. 3′,4′-Dimethoxyflavone is also an aryl hydrocarbon receptor antagonist in human breast cancer cells. 3′,4′-Dimethoxyflavone can promote the proliferation of human hematopoietic stem cells. 3′,4′-Dimethoxyflavone has various biological activities, including antioxidant, anti-cancer, anti-inflammatory, anti-atherogenic, hypolipidaemic, and neuroprotective or neurotrophic effects[1][2][3][4].
3′,4′-Dimethoxyflavone (10 and 20 μM) has protection against the reduction in SH-SY5Y viability induced by Methylnitronitrosoguanidine (MNNG) (HY-128612)[2].
3′,4′-Dimethoxyflavone (6.25-25 μM) decreases the levels of PAR induced by MNNG in HeLa cells[2].
3′,4′-Dimethoxyflavone (12.5, 25, 50 and 100 μM; 15-20 h) reduces cortical neuronal death induced by exposure to NMDA (HY-17551)[2].
3′,4′-Dimethoxyflavone (0.1-10 μM; 24 h) exhibits significant inhibition of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-induced EROD activity in MCF-7 and T47D cells[3].
3′,4′-Dimethoxyflavone inhibits AhR-dependent CYP1A1 induction and AhR-mediated inhibition of estrogen-induced gene expression in T47D and MCF-7 breast cancer cells[3].
3′,4′-Dimethoxyflavone (2.5 μM; 7 days) promotes the proliferation of human hematopoietic stem cells[4].

Reference

[1]. Budzianowski J, et al. Lipophilic flavones of Primula veris L. from field cultivation and in vitro cultures. Phytochemistry. 2005 May;66(9):1033-9.
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[2]. Fatokun AA, et al. Identification through high-throughput screening of 4′-methoxyflavone and 3′,4′-dimethoxyflavone as novel neuroprotective inhibitors of parthanatos. Br J Pharmacol. 2013 Jul;169(6):1263-78.
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[3]. Lee JE, et al. 3′,4′-dimethoxyflavone as an aryl hydrocarbon receptor antagonist in human breast cancer cells. Toxicol Sci. 2000 Dec;58(2):235-42.
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[4]. Kaur K, et al. 3′,4′-Dimethoxyflavone and valproic acid promotes the proliferation of human hematopoietic stem cells. Stem Cell Res Ther. 2013 May 24;4(3):60.
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