3,4,5-Trihydroxycinnamic acid decyl ester

• CAT Number: I045419
• CAS Number: 1770778-45-4
• Molecular Formula: C19H28O5
• Molecular Weight: 336.42
• Purity: ≥95%
• Synonyms: decyl (E)-3-(3,4,5-trihydroxyphenyl)prop-2-enoate
• InChI: InChI=1S/C19H28O5/c1-2-3-4-5-6-7-8-9-12-24-18(22)11-10-15-13-16(20)19(23)17(21)14-15/h10-11,13-14,20-21,23H,2-9,12H2,1H3/b11-10+
• InChIKey: OWEKZOWXFBOKOI-ZHACJKMWSA-N
• SMILES: CCCCCCCCCCOC(=O)C=CC1=CC(=C(C(=C1)O)O)O

3,4,5-Trihydroxycinnamic acid decyl ester is an excellent inhibitor of lipid absorption and accumulation, with anti-obesity properties. 3,4,5-Trihydroxycinnamic acid decyl ester is a pancreatic lipase inhibitor, with an EC50 of approximately 0.9 μM[1].
3,4,5-Trihydroxycinnamic acid decyl ester (30 μM) exhibits an inhibitory potency of approximately 92% for pancreatic lipase in vitro[1].
3,4,5-Trihydroxycinnamic acid decyl ester (0.1-40 μM) inhibits pancreatic lipase activity in dose-dependent manner, with an EC50 value being approximately 0.9 μM[1].
3,4,5-Trihydroxycinnamic acid decyl ester inhibits pancreatic lipase in vitro and lipid accumulation during 3T3-L1 cell differentiation[1].
3,4,5-Trihydroxycinnamic acid decyl ester (30-150 mg/kg; p.o.) suppresses a rise in blood triglyceride (TG) levels in mice given corn oil orally[1].

Reference

[1]. Masahiko Imai ,et al. Inhibitory effects of hydroxylated cinnamoyl esters on lipid absorption and accumulation. Bioorg Med Chem. 2015 Jul 1;23(13):3788-95.
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