3,5-bis(acetoxyacetylamino)-4-chlorobenzonitrile

• CAT Number: M024337
• CAS Number: 123548-56-1
• Molecular Formula: C15H14ClN3O6
• Molecular Weight: 367.742
• Purity: ≥95%
• Target: Neuronal Signaling
• Storage: -20°C
• IUPAC Name: [2-[3-[(2-acetyloxyacetyl)amino]-2-chloro-5-cyanoanilino]-2-oxoethyl] acetate
• InChI: InChI=1S/C15H14ClN3O6/c1-8(20)24-6-13(22)18-11-3-10(5-17)4-12(15(11)16)19-14(23)7-25-9(2)21/h3-4H,6-7H2,1-2H3,(H,18,22)(H,19,23)
• InChIKey: VNVBCWREJHKWSG-UHFFFAOYSA-N
• SMILES: CC(=O)OCC(=O)NC1=CC(=CC(=C1Cl)NC(=O)COC(=O)C)C#N

Acreozast is a histamine release inhibitor potentially for the treatment of asthma and atopic dermatitis.

Reference

1: Tohda Y, Muraki M, Kubo H, Nakajima S, Fukuoka M, Watanabe A. Effect of TYB-2285 on early and late bronchial responses and airway hyperreactivity in actively sensitized guinea pigs. Gen Pharmacol. 1998 Aug;31(2):323-8. PubMed PMID: 9688481. 2: Abraham WM, Ahmed A, Cortes A, Sielczak M, Wantanabe A. Effect of TYB-2285 on antigen-induced airway responses in sheep. Pulm Pharmacol. 1996 Feb;9(1):49-58. PubMed PMID: 8843510. 3: Watanabe A, Tominaga T, Shutoh H, Hayashi H, Tsuji J. Effect of TYB-2285 on peritoneal anaphylaxis in passively sensitized rats. Gen Pharmacol. 1998 Aug;31(2):313-7. PubMed PMID: 9688479. 4: Tominaga T, Watanbe A, Tsuji J, Koda A, Nagai H, Kumazawa Y, Shimada H. Effect of TYB-2285 on antigen-induced accumulation of eosinophils into the peritoneal cavity of rats sensitized with Ascaris suum extract. Gen Pharmacol. 1997 Mar;28(3):411-4. PubMed PMID: 9068982. 5: Watanabe A, Tominaga T, Shutoh H, Hayashi H, Tsuji J, Koda A, Nagai H, Kumazawa Y, Shimada H. Effect of TYB-2285 on lung anaphylaxis in actively sensitized rats. Gen Pharmacol. 1997 Feb;28(2):305-9. PubMed PMID: 9013209. 6: Tominaga T, Watanabe A, Tsuji J, Koda A, Nagai H, Kumazawa Y, Shimada H. The effects of TYB-2285 and its metabolites on lymphocyte responses in vitro. Gen Pharmacol. 1997 Sep;29(3):473-5. PubMed PMID: 9378259. 7: Kou K, Hayashi M, Nakajima T, Yoshizawa I, Kawano Y, Shikishima Y, Noma T. [Immunomodulation by TYB-2285 of Dermatophagoides farinae (Df) antigen-induced IFN-gamma and IL-4 production in lymphocytes from children with bronchial asthma]. Arerugi. 1997 Jun;46(6):502-10. Japanese. PubMed PMID: 9277001. 8: Watanabe A, Tominaga T, Shutoh H, Hayashi H, Tsuji J, Koda A, Nagai H, Kumazawa Y, Shimada H. Effect of TYB-2285 on passive cutaneous anaphylaxis in rats. Gen Pharmacol. 1997 Feb;28(2):311-5. PubMed PMID: 9013210. 9: Tominaga T, Watanabe A, Tsuji J, Koda A, Nagai H, Kumazawa Y, Shimada H. Effects of TYB-2285 on the accumulation of eosinophils in the airway induced by antigen exposure in actively sensitized brown Norway rats. Gen Pharmacol. 1997 Feb;28(2):301-3. PubMed PMID: 9013208. 10: Ban M, Taguchi H, Katsushima T, Takahashi M, Shinoda K, Watanabe A, Tominaga T. Novel antiallergic and antiinflammatory agents. Part II: Synthesis and pharmacology of TYB-2285 and its related compounds. Bioorg Med Chem. 1998 Jul;6(7):1077-87. PubMed PMID: 9730245. 11: Muraki M, Tohda Y, Sugihara R, Nagasaka Y, Nakajima S. The effect of TYB-2285 on dual phase bronchoconstriction and airway hypersensitivity in guinea-pigs actively sensitized with ovalbumin. J Pharm Pharmacol. 1994 Nov;46(11):883-6. PubMed PMID: 7897592. 12: Tominaga T, Watanabe A, Hayashi H, Yanagihara Y, Koda A. Effect of TYB-2285 on histamine release from human basophils in the presence/absence of IL-3. Gen Pharmacol. 1993 Mar;24(2):345-8. PubMed PMID: 7683300. 13: Watanabe A, Tominaga T, Hayashi H, Yanagihara Y, Koda A. Effect of TYB-2285 on antigen-induced histamine release from mouse bone marrow-derived persisting cells (P-cells) primed with interleukin-3-containing conditioned medium (IL3-CM). Gen Pharmacol. 1993 Sep;24(5):1207-11. PubMed PMID: 7505757. 14: Tanimukai T, Ihaku D, Matsuyama T. [Role of adhesion molecules (VLA-4) in the asthmatic response to allergens]. Nihon Kyobu Shikkan Gakkai Zasshi. 1995 Nov;33(11):1240-9. Japanese. PubMed PMID: 8583716.