3,5-Difluoro-L-tyrosine

• CAT Number: I014890
• CAS Number: 73246-30-7
• Molecular Formula: C₉H₉F₂NO₃
• Molecular Weight: 217.17
• Purity: ≥95%
• Target: Phosphatase

3,5-Difluoro-L-tyrosine is a functional, tyrosinase-resistant mimetic of tyrosine. 3,5-Difluoro-L-tyrosine can be used to analyze the substrate specificity of protein tyrosine phosphatases (PTPs)[1].3,5-Difluoro-L-tyrosine (F2Y) is a fluorinated tyrosine analog. 3,5-Difluoro-L-tyrosine is compatible with every aspect of library synthesis, screening, and sequence identification. 3,5-Difluoro-L-tyrosine is a good functional mimic of tyrosine, in terms of binding to the active site of PTPs[1].

Reference

[1]. Bhaskar Gopishetty, et al. Synthesis of 3,5-difluorotyrosine-containing peptides: application in substrate profiling of protein tyrosine phosphatases. Org Lett. 2008 Oct 16;10(20):4605-8.