3,5-Diiodo Thyroacetic Acid

• CAT Number: R011611
• CAS Number: 1155-40-4
• Molecular Formula: C14H10I2O4
• Molecular Weight: 496.039
• Purity: ≥95%
• Synonyms: 4-(4-Hydroxyphenoxy)-3,5-diiodobenzeneacetic Acid; [4-(p-Hydroxyphenoxy)-3,5-diiodophenyl]acetic Acid; Diac; NSC 90463
• Storage: -20°C
• IUPAC Name: 2-[4-(4-hydroxyphenoxy)-3,5-diiodophenyl]acetic acid
• InChI: InChI=1S/C14H10I2O4/c15-11-5-8(7-13(18)19)6-12(16)14(11)20-10-3-1-9(17)2-4-10/h1-6,17H,7H2,(H,18,19)
• InChIKey: KKJBNMLZBHFYAE-UHFFFAOYSA-N
• SMILES: C1=CC(=CC=C1O)OC2=C(C=C(C=C2I)CC(=O)O)I

3,5-Diiodothyroacetic acid (diac) is the acetic acid variant of thyroxine. Formulations containing dosages in the range of 100 mg/day decrease serum cholesterol and produce calorigenic effects in humans. Formulations containing diac also protect human LDL cholesterol from oxidation in vitro. Diac treatment prevents elevated liver cholesterol in rats fed a high-fat diet and reduces previously elevated liver cholesterol to control levels.