3',5'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)uridine

• CAT Number: L034471
• CAS Number: 69304-38-7
• Molecular Formula: C21H38N2O7Si2
• Molecular Weight: 486.70
• Purity: ≥95%
• IUPAC Name: 1-[(6aR,8R,9R,9aS)-9-hydroxy-2,2,4,4-tetra(propan-2-yl)-6a,8,9,9a-tetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl]pyrimidine-2,4-dione
• InChI: InChI=1S/C21H38N2O7Si2/c1-12(2)31(13(3)4)27-11-16-19(29-32(30-31,14(5)6)15(7)8)18(25)20(28-16)23-10-9-17(24)22-21(23)26/h9-10,12-16,18-20,25H,11H2,1-8H3,(H,22,24,26)/t16-,18-,19-,20-/m1/s1
• InChIKey: KKLQDUCRZCCKHG-VBSBHUPXSA-N
• SMILES: CC(C)[Si]1(OC[C@@H]2[C@H]([C@H]([C@@H](O2)N3C=CC(=O)NC3=O)O)O[Si](O1)(C(C)C)C(C)C)C(C)C

3′,5′-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)uridine（Cat No.:L034471）is a modified nucleoside that features a disiloxane linker between the 3′ and 5′ hydroxyl groups of uridine. This modification enhances stability against nucleases, potentially improving the pharmacokinetic properties of oligonucleotides in therapeutic applications. The disiloxane moiety may also influence binding affinity and hybridization characteristics, making it a valuable tool in the design of nucleic acid-based drugs and molecular probes. Research on this compound focuses on its utility in RNA interference and antisense therapy, aiming to develop more effective nucleic acid therapeutics.